IMG [AS-SIG/Image]

Abstract submission

AS-SIG will consist of a mixture of invited talks, and talks and posters selected from submitted abstracts. Talks will be selected from submitted long abstracts based on scientific quality and novelty. Selected speakers are asked to present a 30 minute talk (including discussion), and the talk abstracts will be published in the SIG proceedings.
Abstracts are invited in, but not limited to, the following areas:

Experimental and bioinformatics methodologies for alternative splicing
    Experimental methods, RT-PCR-based screens; minigene systems; RNA interference-mediated screens; splicing-sensitive DNA microarrays, cross-linking and immunoprecipitation (CLIP-) based screens; small molecule approaches.
    AS information and databases, transcript repositories; standards for annotating primary transcript structures; data exchange formats; structure of AS information, ontologies, abstract representations of AS events.
    Algorithms and genome analyses, spliced-alignments; new tools for data-mining, computational analysis of AS events, types and rates, AS gene products and functional impact; comparative genomics and evolution of introns and AS.
IMG [AS-SIG/Image]
Biology of regulatory mechanisms of alternative splicing
    Regulatory mechanisms of splicing, functional nucleotide sequences as cis-regulatory elements; splicing-regulatory SR proteins and hnRNPs; methods to infer novel splicing regulators; NMD as a surveillance (quality control) pathways linked to AS.
    Biological function, impact of splice variants on protein structure and biological pathways; relation of pre-mRNA splicing with other mechanism of gene expression; differentiation of AS regulation and functional impact between model organisms.
Aberrant splicing, human disease, and concepts for medical treatment
    Disease biomarkers, Identification and characterization of splicing mutations and variations linked to human disease; classification of AS forms based on disease progression; diagnostic tools related to AS pattern variation linked to disease.
    Medical applications, therapeutic strategies related to splicing variations between normal and diseases states; correction of disease-associated splicing defects; splicing regulators as drug targets.


Please submit an extended abstract of one to two pages in RTF format (paper size US Letter) to the program committee, using the template provided below. Please indicate if you wish to present a talk, or poster or either.