IMG [AS-SIG/Image]

Program, July 19th

REGULATORY MECHANISMS OF SPLICING

09.00 - 09.45
Cellular programs of alternative splicing regulation, Juan Valcarcel

09.45 - 10.30
Splicing, Silencing and Nonsense, Chris Smith [pdf]


10.30 - 11.00 Coffee break


11.00 - 11.20
Pre-mRNA secondary structures affect the splicing outcome, Michael Hiller [ppt]

11.20 - 11.40
Computational analysis of alternative humann exons originating from tandem donors, Ralf Bortfeldt [pdf]

11.40 - 12.00
Violating the splicing rules: TG dinucleotides function as alternative splice sites in U2-dependent introns, Karol Szafranski [ppt]


12.00 - 13.30 Lunch break

IMG [AS-SIG/Image]
13.30 - 14.15 Alternative splicing in C.elegans: genetic, genomic and molecular approaches to understanding regulation, Alan Zahler

14.15 - 15.00 SR protein splicing factors as targets for therapy, Jamal Tazi

EVOLUTION OF ALTERNATIVE SPLICING

15.00 - 15.20 Evolutionary conserved alternative splicing, Maria Kalyna


15.30 - 16.00 Coffee break


16.00 - 16.20 Exonization and establishment in human genes, Eduardo Eyras [pdf]

16.20 - 16.40 Patterns of selection and evolution of the exon-intron structure in alternatively spliced genes, Ekaterina Ermakova


17.00 - 18.30 Poster session


19.00 Conference dinner

Program, July 20th

ALTERNATIVE SPLICING AND FUNCTION

09.00 - 09.45 Functional coordination and evolution of mammalian alternative splicing, Benjamin Blencowe

09.45 - 10.05 Discovery of tissue-specific exons using comprehensive human exon microarrays, Tyson Clark

10.05 - 10.25 Alternative splicing profiling and regulation in human body tissues, John Castle [ppt]


10.30 - 11.00 Coffee break


11.00 - 11.20 Transcript isoform entropy: proof of extensive disruption in cancerous tissues, William Ritchie [ppt]

11.20 - 11.40 Alternative splicing expands the human transcriptome and proteome by one order of magnitude, Graziano Pesole [pdf]

11.40 - 12.00 Comprehensive analysis of alternative splicing in the chicken, Shoba Ranganathan


12.00 - 13.30 Lunch break

GENOMICS AND BIOINFORMATICS OF SPLICING

13.30 - 14.20 Exonic splicing motifs and the design of synthetic exons, Larry Chasin [pdf]

14.20 - 14.40 Murky beginnings and alternate ends: transcript diversity at 5'- and 3'-ends, Uwe Ohler [pdf]

14.40 - 15.00 Computational evidence for the association between transcription initiation and internal splicing, Mihaela Zavolan [pdf]

15.00 - 15.20 Bootstrapping the alternative splicing annotation of newly sequenced genomes, Cheng Soon


15.30 - 16.00 Coffee break


16.00 - 16.20 The Alternative Splicing and Transcript Diversity Database, Elenore Whitfield [ppt]

16.20 - 16.40 Splicing isoforms in the ENCODE complement, Michael Tress


16.40 Conclusion